‘Big Mouth’ Season 5: Coming to Netflix in November 2021 & What We Know So Far

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big mouth season 5 everything we know so far

Big Mouth – Copyright. Netflix

There’s lots more to come as Big Mouth season 5 is coming to Netflix in November 2021. We’ll be keeping track of everything related to season five of Big Mouth, including what to expect, casting, news, trailers, and the Netflix release date.

Big Mouth is a Netflix Original adult-animated sitcom created by Nick Kroll, Andrew Goldberg, Mark Levin, and Jennifer Flackett. The series is loosely based on the upbringing of Nick Kroll and Andrew Goldberg and their own experiences of puberty throughout their youth.

The series has fast become the flagship show for its line up of adult-animated content.

When is the Big Mouth season five Netflix release date?

During the Netflix TUDUM event, creator and actor of Big Mouth Nick Kroll revealed that Big Mouth season 5 is coming to Netflix on Friday, November 5th, 2021.

What to expect from Big Mouth season five.

After an anxiety-filled season of Big Mouth, Nick, Andrew, and their friends were able to overcome some of their fears. As they all begin to come to terms with who they are as people allowed Tito the Mosquito to dramatically decrease in size, and in Jessie’s case, to be eaten by the Gratitoad.

Next season we may see the gang as more confident individuals thanks to overcoming their anxiety. But, like all the other hormonal teenagers learning about the world, we can expect to see more creatures of the hormonal kind invade their lives at the worst possible time.


Nick fell out with his former best friend Andrew at the end of season three, but by the time camp was over he had reconciled with his best friend. Struggling with anxiety, Nick was finally able to overcome the anxious thoughts about the future and defeated his evil alter ego with the help of his friends.

We can expect Nick to be more confident next season, but with Rick as his hormone monster still, he’ll still struggle with the problems of being a teenager.

Big mouth season 4 nick anxiety

– Copyright. Netflix


After thinking that breaking his masturbation routine killed his grandfather, Andrew suffered the humiliating experience of masturbating at his grandfather’s open casket and being caught in the act. Andrew’s mother and father didn’t help his confusion and only made him more anxious about death. Like Nick, it took the help of his friends and to overcome his anxiety.

Like Nick, expect Andrew to be looking for a girlfriend in the next season. You can also expect future visits from the shame wizard as Andrew always allows himself to get into shameful situations.

big mouth season 5 andrew


Another sufferer of Anxiety, Jessie also suffered from depression throughout the season. But what helped her overcome her struggles was Nick and her friends, not to mention the support of Connie the Hormone Monstress.

Jessie’s return to Bridgerton High School immediately relieves the pressure she felt from inner-city life. While she still suffers from depression and anxiety, Tito and the Depression Kitty have dramatically lost their hold on her.

Big mouth season 4 jessie

Jessie overcame her anxiety and depression – Copyright. Netflix


Missy came into her own in the fourth season of Big Mouth and starting to come to terms with her own identity. As she embraces her black heritage, Missy received a wardrobe change, a change in voice actress, and a potential future boyfriend in DeVon.

Mona has been a powerful influence on Missy, and we can only expect more hilarious antics as Mona continues to lead Missy down the horny path.

Big mouth season 4 missy

Missy has gone through her own awakening as she embraces her racial identity – Copyright. Netflix

Lola and Jay

After a whirlwind romance, the Bonnie and Clyde of the series, Lola and Jay are now no longer together. Despite finally coming to terms with her feelings for Jay, the young hot-blooded male had already cheated on her with both of his pillows, sending Lola into a rage. Declaring war on Jay, and stating he is “f***ed” next season.

Thanks to Lola’s declaration, expect to see the pair to go to war with each other in season five.

big mouth lola and jay

Lola and Jay, the Bonnie and Clyde of Big Mouth – Copyright. Netflix


With each subsequent season, Matthew continues to receive more and more screen time. This season saw his coming out to both parents, and while his mother has outwardly rejected him, Mathew’s father had already figured out his son’s sexuality and seemingly come to terms with it.

Next season is likely to explore the balance between his home life, and his relationship with boyfriend Aiden. Fully supported by Maury, expect the hormone monster to encourage Matthew to explore his relationship with Aiden further.

big mouth season 5 matthew

Maury has been a very supportive hormone monster for Matthew – Copyright. Netflix

Who are the cast members of Big Mouth season five?

We can expect to see the following cast members return for the fifth season of Big Mouth:

Cast Member Voices
Nick Kroll Nick Birch | Maury the Hormone Monster | Coach Steve | Lola
Maya Rudolph Connie the Hormone Monstress
John Mulaney Andrew Glouberman | Babe the Blue Ox
Jessi Klein Jessi Glaser
Jason Mantzoukas Jay Bilzerian
Ayo Edebiri Missy Foreman-Greenwald
Andrew Rannells Matthew
Thandie Newton Mona the Hormone Monstress

Jenny Slate stepped down from her role as Missy during the fourth season of Big Mouth, with Ayo Edebiri taking over the role in the episode 4×9 “Horrority House.” From season five onward, the role will be played exclusively by Ayo Edebiri.

The series has seen plenty of guest roles, but we’re yet to learn of any new stars set to make an appearance.

Can we expect to see a sixth season of Big Mouth on Netflix?

It’s already been confirmed that Big Mouth will be returning for the sixth season. When Netflix renewed the series for its fourth season, renewal for seasons five and six were confirmed at the same time. It’s unusual for Netflix to renew a series for multiple seasons, but this only exemplifies how much confidence the streaming service has with the series.

Are you excited for the fifth season of Big Mouth on Netflix? Let us know in the comments below!

Written by

Jacob joined What's on Netflix in 2018 as a fulltime writer having worked in numerous other industries until that point. Jacob covers all things Netflix whether that's TV or movies but specializes in covering new anime and K-dramas. Resides in Norwich in the United Kingdom.